![]() ![]() PLoS ONE 9(3):Įditor: Roland Seifert, Medical School of Hannover, Germany (2014) Comparative Expression Study of the Endo–G Protein Coupled Receptor (GPCR) Repertoire in Human Glioblastoma Cancer Stem-like Cells, U87-MG Cells and Non Malignant Cells of Neural Origin Unveils New Potential Therapeutic Targets. The comparative GPCR expression study presented here gives clues for new pathways specifically used by GSCs and unveils novel potential therapeutic targets.Ĭitation: Fève M, Saliou J-M, Zeniou M, Lennon S, Carapito C, Dong J, et al. Results of GPCR expression at the protein level using mass spectrometry and proteomic analysis are also presented. Seventeen GPCRs appeared specifically expressed in cells with stem properties (GSCs and f-NSCs). ![]() At the transcriptomic level, eight GPCRs were specifically expressed/overexpressed in GSCs. Of the 356 GPCRs investigated, 138 were retained for comparative studies between the different cell types. The endo-GPCR transcriptome has been studied using Taqman Low Density Arrays. Here, we report a descriptive study of the differential expression of the endo-GPCR repertoire in human glioblastoma cancer stem-like cells (GSCs), U-87 MG cells, human astrocytes and fetal neural stem cells (f-NSCs). Their role in cancer has been highlighted but remains largely unexplored. G-protein coupled receptors (GPCRs), a family of membrane receptors, play a prominent role in cell signaling, cell communication and crosstalk with the microenvironment. These cells, termed cancer stem-like cells, have been designed as prominent targets for new and more efficient cancer therapies. Among these, cells endowed with stem properties, tumor initiating/propagating properties and particularly resistant to chemo- and radiotherapies are designed as the real culprits for tumor maintenance and relapse after treatment. These tumors are heterogeneous being constituted by a variety of cells in different states of differentiation. Glioblastomas (GBMs) are highly aggressive, invasive brain tumors with bad prognosis and unmet medical need. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |